NIDA Opioid-Cocaine Genetics Initiative Version 1.0 (Aug 2019)

DESCRIPTIVE INFORMATION BY DIAGNOSTIC MODEL

' M1 M2 M3
PEDIGREES WITH AN AFFECTED SIB-PAIR WITH DNA AVAILABLE      
# sibships, 2 affected sibs with DNA available 535 237 467
# sibships, 3 affected sibs with DNA available 61 17 48
# sibships, 4 affected sibs with DNA available 9 2 7
# sibships, 5 or more affected sibs with DNA available 1 0 1
Total # pedigrees,at least 1 affected sib-pair with DNA available 603 256 520
# affected sib-pairs with DNA available (n-1) 688 277 588
Maximum # affected sib-pairs with DNA available [n*(n-1)/2] 782 300 663
# affected sibs with DNA available 1294 533 1111
# other affected relatives with DNA available 50 19 39
Total # affecteds with DNA available 1344 552 1150
# unaffected sibs with DNA available 68 31 73
# other unaffected relatives with DNA available 138 65 121
Total # subjects with DNA available 1550 648 1344
# sibships, no parent with DNA available 476 199 412
# sibships, 1 parent with DNA available 111 48 97
# sibships, both parents with DNA available 19 9 14
# afffecteds with DNA available, by sex      
Female 652 236 580
Male 691 315 569
PEDIGREES WITHOUT AN AFFECTED SIB-PAIR WITH DNA AVAILABLE      
# pedigrees, one affected with DNA available 79 211 143
# pedigrees, 2 affecteds with DNA available 93 31 90
# pedigrees, 3 affecteds with DNA available 14 1 13
# pedigrees, 4 affecteds with DNA available 3 1 2
# sibships, 5 or more affecteds with DNA available 1 0 1
Total # pedigrees, at least 1 affected with DNA available 190 244 249
Total # affecteds with DNA available 325 280 375
Total # subjects with DNA available 423 1325 629
TRIOS FOR ASSOCIATION ANALYSIS      
(AN AFFECTED INDIVIDUAL + 2 PARENTS WITH DNA AVAILABLE)      
# pedigrees containing at least 1 trio 25 19 21
INDEPENDENT CASES AND CONTROLS      
# independent cases 793 500 769
# potential controls from Control Sample 0 0 0

MODEL 1: DSM-III-R, DSM-IV Opioid or Cocaine Dependence

MODEL 2: DSM-III-R, DSM-IV Opioid Dependence

MODEL 3: DSM-III-R, DSM-IV Cocaine Dependence