NIDA Opioid-Cocaine Genetics Initiative Version 1.0 (Aug 2019)

DESCRIPTIVE INFORMATION BY DIAGNOSTIC MODEL

'	M1	M2	M3
PEDIGREES WITH AN AFFECTED SIB-PAIR WITH DNA AVAILABLE
# sibships, 2 affected sibs with DNA available	535	237	467
# sibships, 3 affected sibs with DNA available	61	17	48
# sibships, 4 affected sibs with DNA available	9	2	7
# sibships, 5 or more affected sibs with DNA available	1	0	1
Total # pedigrees,at least 1 affected sib-pair with DNA available	603	256	520
# affected sib-pairs with DNA available (n-1)	688	277	588
Maximum # affected sib-pairs with DNA available [n*(n-1)/2]	782	300	663
# affected sibs with DNA available	1294	533	1111
# other affected relatives with DNA available	50	19	39
Total # affecteds with DNA available	1344	552	1150
# unaffected sibs with DNA available	68	31	73
# other unaffected relatives with DNA available	138	65	121
Total # subjects with DNA available	1550	648	1344
# sibships, no parent with DNA available	476	199	412
# sibships, 1 parent with DNA available	111	48	97
# sibships, both parents with DNA available	19	9	14
# afffecteds with DNA available, by sex
Female	652	236	580
Male	691	315	569
PEDIGREES WITHOUT AN AFFECTED SIB-PAIR WITH DNA AVAILABLE
# pedigrees, one affected with DNA available	79	211	143
# pedigrees, 2 affecteds with DNA available	93	31	90
# pedigrees, 3 affecteds with DNA available	14	1	13
# pedigrees, 4 affecteds with DNA available	3	1	2
# sibships, 5 or more affecteds with DNA available	1	0	1
Total # pedigrees, at least 1 affected with DNA available	190	244	249
Total # affecteds with DNA available	325	280	375
Total # subjects with DNA available	423	1325	629
TRIOS FOR ASSOCIATION ANALYSIS
(AN AFFECTED INDIVIDUAL + 2 PARENTS WITH DNA AVAILABLE)
# pedigrees containing at least 1 trio	25	19	21
INDEPENDENT CASES AND CONTROLS
# independent cases	793	500	769
# potential controls from Control Sample	0	0	0

MODEL 1: DSM-III-R, DSM-IV Opioid or Cocaine Dependence

MODEL 2: DSM-III-R, DSM-IV Opioid Dependence

MODEL 3: DSM-III-R, DSM-IV Cocaine Dependence