NIDA Poly Substance Dependence Genetics Initiative Version 4.0 (Aug 2019)

DESCRIPTIVE INFORMATION BY DIAGNOSTIC MODEL

'	M1	M2	M3	M4	M5	M6	M7	M8
PEDIGREES WITH AN AFFECTED SIB-PAIR WITH DNA AVAILABLE
# sibships, 2 affected sibs with DNA available	102	1	4	77	13	0	78	108
# sibships, 3 affected sibs with DNA available	3	0	0	2	0	0	4	8
# sibships, 4 affected sibs with DNA available	1	0	0	0	0	0	0	1
# sibships, 5 or more affected sibs with DNA available	0	0	0	0	0	0	0	0
Total # pedigrees,at least 1 affected sib-pair with DNA available	106	1	4	79	13	0	82	117
# affected sib-pairs with DNA available (n-1)	111	1	4	81	13	0	86	127
Maximum # affected sib-pairs with DNA available [n*(n-1)/2]	117	1	4	83	13	0	90	138
# affected sibs with DNA available	217	2	8	160	26	0	168	244
# other affected relatives with DNA available	6	1	0	2	0	0	8	0
Total # affecteds with DNA available	223	3	8	162	26	0	176	244
# unaffected sibs with DNA available	39	0	3	27	6	0	26	40
# other unaffected relatives with DNA available	98	0	5	77	15	0	87	129
Total # subjects with DNA available	360	3	16	266	47	0	289	413
# sibships, no parent with DNA available	23	0	0	19	2	0	11	19
# sibships, 1 parent with DNA available	56	0	3	36	7	0	42	67
# sibships, both parents with DNA available	21	0	1	19	4	0	24	31
# afffecteds with DNA available, by sex
Female	78	1	4	50	15	0	61	83
Male	145	2	4	112	11	0	115	161
PEDIGREES WITHOUT AN AFFECTED SIB-PAIR WITH DNA AVAILABLE
# pedigrees, one affected with DNA available	771	144	240	756	167	49	632	452
# pedigrees, 2 affecteds with DNA available	85	11	12	39	2	0	61	0
# pedigrees, 3 affecteds with DNA available	10	1	0	3	0	0	4	0
# pedigrees, 4 affecteds with DNA available	0	0	0	0	0	0	0	0
# sibships, 5 or more affecteds with DNA available	0	0	0	0	0	0	0	0
Total # pedigrees, at least 1 affected with DNA available	866	156	252	798	169	49	697	452
Total # affecteds with DNA available	971	169	264	843	171	49	766	452
Total # subjects with DNA available	3105	3462	3449	3199	3418	3465	3176	3052
TRIOS FOR ASSOCIATION ANALYSIS
(AN AFFECTED INDIVIDUAL + 2 PARENTS WITH DNA AVAILABLE)
# pedigrees containing at least 1 trio	130	18	27	124	24	3	107	75
INDEPENDENT CASES AND CONTROLS
# independent cases	972	157	256	877	182	49	779	569
# independent controls in distribution file	0	0	0	0	0	0	0	0

M1: DSM-IV Illicit Drug Dependence/ Disorder (opioid, cocaine, cannabis, sedative, stimulant, other)

M2: DSM-IV Opioid Dependence/ Disorder

M3: DSM-IV Cocaine Dependence/ Disorder

M4: DSM-IV Cannabis Dependence/ Disorder

M5: DSM-IV Stimulant Dependence/ Disorder

M6: DSM-IV Sedative Dependence/ Disorder

M7: DSM-IV Alcohol Dependence/ Disorder

M8: DSM-IV Nicotine Dependence/ Disorder