The following studies have contributed to our Polysubstance Dependence datasets.
Study 11 – Adolescent Drug Dependence
Investigator: John Hewitt (former PI Thomas Crowley) Status: Available at NIDA Repository NIDA Release Date: June 2013 Abstract: The R01 response to RFA Da-99-003 proposes a multi-site whole-genome search for chromosomal loci influencing early-onset antisocial drug dependence. This project extends Colorado’s ongoing sib-pair study of clinical probands with sever SD and CD, based on the QTL methodology developed by our...
Study 12 – Substance Abuse and the Dopamine System Genes
Investigator: Michael M. Vanyukov Status: Available at NIDA Repository NIDA Release Date: January 2011 Abstract: Variation in the risk for substance use disorder (SUD) results from the interaction of genetic and environmental factors. Molecular genetic studies may help disentangle these factors.The Substance Abuse and the Dopamine System Genes (SADS) project examines the role of DNA polymorphisms, personality and environmental factors...
Study 19 – Epidemiological Study of Substance Abuse
Investigator: Rob Philibert Status: Available at NIDA Repository NIDA Release Date: December 2013 Abstract (adapted from the applicant’s abstract): The purpose of this project is to add a molecular genetic component to the extensive epidemiologic data on Substance Use Disorders (SUD) available in the Iowa Adoption Studies. These epidemiologic studies include over 900 adult adoptees, separated at birth from biologic...
Study 21 – Twin Family Study of Vulnerability to Substance Abuse
Investigator: William G. Iacono Status: Combined with NIDA Study 25 Release Date: 06/24/2015 Abstract: Our study seeks to identify genetic and environmental influences on the development of substance abuse. It uses a prospective cohort research design to follow twins longitudinally from childhood, through adolescence and into early adulthood. This design allows us to identify initial experimentation; persistence of licit and...
Study 22 – Exploring the Genetic Basis for Drug Use
Investigator: Hallam Hurt, M.D. Status: Closed Abstract: This protocol will begin a long-term project to study characteristics that are associated with drug use by adolescents and young adults. Early drug use is known be related to a number of factors, both environmental and genetic. Environmental factors include how carefully parents or caregivers monitor children’s activities, and whether the children’s friends...
Study 23 – Substance Use Disorder Liability: Candidate Gene System
Investigator: Michael M. Vanyukov Status: Available at NIDA Repository NIDA Release Date: August 2019 Abstract: This study seeks to elucidate the role that a large set of genes comprehensively representing neurobiological systems involved in drug-related processes plays in the risk for substance use disorders (SUD). The concurrent genetic investigation of the major neurochemical systems that have been shown to work...
Study 45 – Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB); CTN-0110
Principal Investigators: Steve Shoptaw, Ph.D. (University of California, Los Angeles), Madhukar H. Trivedi, M.D. (University of Texas Southwestern Medical Center) Site Investigators: Erik Anderson, M.D., Andrew Herring, M.D. (Alameda Health System), Tara Chowdhury, Ph.D. (COGA, Inc.), Julie Croff, Ph.D., MPH, FAAHB (Oklahoma State University), Sidarth Wakhlu, M.D. (University of Texas Southwestern Medical Center), Judith Tsui, M.D. (University of Washington) Timothy...