The following studies have contributed to our Nicotine Dependence datasets.
Study 02 – Mapping Susceptibility Genes for Nicotine Dependence
Investigator: Ming D. Li Status: Available at NIDA Abstract: Despite increasingly negative public sentiment toward the use of tobacco products and legislation that both reduces the availability of cigarettes and the public places where smoking is permitted, virtually no further reduction in smoking has occurred in this country during the 1990's. According to the 1996 National Household Survey on Drug...
Study 06 – The Genetics of Vulnerability to Nicotine
Investigator: Pamela Madden Status: Available at NIDA and dbGaP dbGaP Accession ID: phs001299.v2.91 Abstract: This study focuses on two primary smoking phenotypes: (i) a broader phenotype, lifetime heavy smoking, which is the phenotype being used to define affected sib pairs and hence which determines selection of families for genotyping; and (ii) a narrower phenotype of lifetime nicotine dependence, which requires...
Study 09 – Differentiation of Phenotypes for Smoking: Administrative Supplement to Join NIDA Genetics Consortium
Investigators: Ovide Pomerleau, Cindy Pomerleau Status: Available at NIDA Summary This project builds on NIDA grant R01 DA06529, which was designed to provide accurate identification and characterization of two important phenotypes by partitioning the effects of 1) nicotine dependence and 2) depression, using baseline data as well as laboratory testing of behavioral, physiological, and neuroendocrine response to smoking abstinence. The...
Study 10 – Pharmacokinetics of Nicotine in Twins
Investigator: Gary E. Swan (SRI International) Status: Available at NIDA Abstract: Despite the best efforts to date, 46 million people still smoke, and, people die from tobacco-related illness annually; the estimated smoking-related cost to the economy is $72 billion annually. The question remains why some people smoke and not others. The proposed research plan seeks to explore, for the first...
Study 15 – Nicotine Dependence
Investigators: Laura Bierut, Naomi Breslau, Sharon Murphy Status: Available at NIDA Abstract: Tobacco use, primarily through cigarette smoking, is the largest cause of preventable mortality in the world (WHO, 2006), and nicotine is the component in tobacco that is responsible for the maintenance of smoking. Because of increasing tobacco use in developing nations, it is predicted that the death toll...
Study 16 – Nicotine Dependence
Investigator: Mark Leppert Status: Available at NIDA Abstract: Not Available Files Instrument NIDA_Study16_docDownload References NIDA Study 16 ReferencesDownload
Study 27 – The Genetic Study of Nicotine Dependence in African Americans (AAND)
Investigators: Laura Bierut, Ph.D. (Washington University School of Medicine), Eric Johnson, Ph.D. (Research Trangle Institute International) Status: Available at NIDA Abstract: The overarching goal of this project is to identify and characterize genetic determinants of nicotine dependence in a large African-American population. This proposal builds on the foundation laid in the Collaborative Genetic Study of Nicotine Dependence (COGEND), in which...
Study 35 – Genetically Informative Smoking Cessation Trial
Investigator: Li-Shiun Chen Release Date: Available at NIDA Purpose of the study: The goal of this genetically informed randomized smoking cessation trial is to identify the most appropriate smoking cessation treatments for smokers based on genetic information. Background: In a general population sample of smokers seeking to quit, we recently discovered that genetic markers in the CHRNA5 gene predict cessation...