Polysubstance Dependence

The following studies have contributed to our Polysubstance Dependence datasets.

Study 11 – Adolescent Drug Dependence

Investigator:  John Hewitt (former PI Thomas Crowley) Release Date: Available at NIDA and dbGaP Abstract:  The R01 response to RFA Da-99-003 proposes a multi-site whole-genome search for chromosomal loci influencing early-onset antisocial drug dependence.  This project extends Colorado’s ongoing sib-pair study of clinical probands with sever SD and CD, based on the QTL methodology developed by our colleagues, Fulker, Cherny...

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Study 12 – Substance Abuse and the Dopamine System Genes

Investigator:  Michael M. Vanyukov Release Date:  Available at NIDA Abstract:  Variation in the risk for substance use disorder (SUD) results from the interaction of genetic and environmental factors. Molecular genetic studies may help disentangle these factors.The Substance Abuse and the Dopamine System Genes (SADS) project examines the role of DNA polymorphisms, personality and environmental factors in variation in the liability...

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Study 19 – Epidemiological Study of Substance Abuse

Investigator: Rob Philibert Release Date:  Available at NIDA Abstract (adapted from the applicant’s abstract): The purpose of this project is to add a molecular genetic component to the extensive epidemiologic data on Substance Use Disorders (SUD) available in the Iowa Adoption Studies.  These epidemiologic studies include over 900 adult adoptees, separated at birth from biologic parents, interviewed over a 20...

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Study 21 – Twin Family Study of Vulnerability to Substance Abuse

Investigator:  William G. Iacono Release Date:  Combined with NIDA Study 25 Abstract:  Our study seeks to identify genetic and environmental influences on the development of substance abuse. It uses a prospective cohort research design to follow twins longitudinally from childhood, through adolescence and into early adulthood. This design allows us to identify initial experimentation; persistence of licit and illicit substances;...

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Study 22 – Exploring the Genetic Basis for Drug Use

Investigator:  Hallam Hurt, M.D. Release Date:  Closed Abstract:  This protocol will begin a long-term project to study characteristics that are associated with drug use by adolescents and young adults.  Early drug use is known be related to a number of factors, both environmental and genetic.  Environmental factors include how carefully parents or caregivers monitor children’s activities, and whether the children’s...

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Study 23 – Substance Use Disorder Liability: Candidate Gene System

Investigator:  Michael M. Vanyukov Release Date:  Available at NIDA Abstract:  This study seeks to elucidate the role that a large set of genes comprehensively representing neurobiological systems involved in drug-related processes plays in the risk for substance use disorders (SUD). The concurrent genetic investigation of the major neurochemical systems that have been shown to work in concert in drug-related behavior...

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Study 45 – Randomized, Double-Blind, Placebo-Controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB); CTN-0110

Principal Investigators: Steve Shoptaw, Ph.D. (University of California, Los Angeles), Madhukar H. Trivedi, M.D. (University of Texas Southwestern Medical Center) Site Investigators: Erik Anderson, M.D., Andrew Herring, M.D. (Alameda Health System), Tara Chowdhury, Ph.D. (COGA, Inc.), Julie Croff, Ph.D., MPH, FAAHB (Oklahoma State University), Sidarth Wakhlu, M.D. (University of Texas Southwestern Medical Center), Judith Tsui, M.D. (University of Washington) Timothy...

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