The Opioid-Cocaine Dependence Genetics Initiative

This initative aims to gather data from Opioid/Cocaine Dependence studies in Center and release the data in a series of distributions.

The following information is for Distribution 2.0. More detailed information can be found in ourĀ query tool, including customizable breakdowns by biomaterials, demographics and disease.

Biomaterials, Clinical Instruments and Demographics

ItemValue
DistributionOpioid-Cocaine Dependence 2.0
Subjects6,730
With DNA5,067 (75.29%)
With Plasma29 (0.43%)
Instrument: DSM-IV4,977 (73.95%)
Instrument: Unknown1,753 (26.05%)
Females / Males / Unknown2,891 (42.96%) / 3,818 (56.73%) / 21 (0.31%)
AgeAverage: 39.8, Min: 17, Max: 79
Race: African-American2,905 (43.16%)
Race: American Indian25 (0.37%)
Race: Asian5 (0.07%)
Race: Hispanic388 (5.77%)
Race: Pac Islander3 (0.04%)
Race: White2,371 (35.23%)
Race: Other1,033 (15.35%)

Diseases

DiseaseAffectedUnaffectedOther
Opioid Dependence2,738 (40.68%)2,128 (31.62%)1,864 (27.7%)
Cocaine Dependence4,250 (63.15%)582 (8.65%)1,898 (28.2%)
Alcohol Dependence847 (12.59%)631 (9.38%)5,252 (78.04%)
Nicotine Dependence1,271 (18.89%)634 (9.42%)4,825 (71.69%)
Marijuana Dependence501 (7.44%)1,111 (16.51%)5,118 (76.05%)
Stimulant Dependence111 (1.65%)1,734 (25.77%)4,885 (72.59%)
Sedative Dependence130 (1.93%)1,707 (25.36%)4,893 (72.7%)
Other Drug Dependence322 (4.78%)1,497 (22.24%)4,911 (72.97%)
Opioid Abuse113 (1.68%)2,130 (31.65%)4,487 (66.67%)
Cocaine Abuse146 (2.17%)582 (8.65%)6,002 (89.18%)
Alcohol Abuse431 (6.4%)631 (9.38%)5,668 (84.22%)
Marijuana Abuse297 (4.41%)1,111 (16.51%)5,322 (79.08%)
Stimulant Abuse64 (0.95%)1,734 (25.77%)4,932 (73.28%)
Sedative Abuse72 (1.07%)1,707 (25.36%)4,951 (73.57%)
Other Drug Abuse84 (1.25%)1,497 (22.24%)5,149 (76.51%)

Citing this Dataset

If you use this dataset in your research, please cite the overall Center as “National Institute on Drug Abuse Center for Genetic Studies (RRID:SCR_013061)”.

Contributing PIs

Joel Gelernter, Kathleen Brady, Henry Kranzler, Roger Weiss, David Oslin