Study 15 – Nicotine Dependence

Investigators:  Laura Bierut, Naomi Breslau, Sharon Murphy

Status:  Available at NIDA

Abstract:  Tobacco use, primarily through cigarette smoking, is the largest cause of preventable mortality in the world (WHO, 2006), and nicotine is the component in tobacco that is responsible for the maintenance of smoking.  Because of increasing tobacco use in developing nations, it is predicted that the death toll from tobacco worldwide will rise from the current 5 million to more than 10 million per year by 2020.

Nicotine dependence is a common, etiologically complex behavior; the development of dependence is influenced by underlying biological factors, environmental features, and interactions among genes and between genes and environments.  The overall goals of COGEND are the identification of genes, environmental features, and biological mechanisms that predispose or protect individuals from the onset and persistence of nicotine dependence.   Improved understanding of these factors will suggest novel, powerful strategies for reducing or eliminating tobacco consumption and decreasing the burden of morbidity and mortality that follows.


Semi-Structured Assessment of Nicotine Dependence (SSAND)


Michigan Nicotine Reinforcement Questionnaire (M NRQ)

Pomerleau OF, Fagerstrom K-O, Marks JL, Tate JC, Pomerleau CS.  Development and validation of a self-rating scale for positive- and negative- reinforcement smoking: The Michigan Nicotine Reinforcement Questionnaire.  Nicotine Tob Res 2003; 5(5):711-718.

Nicotine Dependence Syndrome (NDSS)

RAND 36-Item Health Survey

Online Interview (This link will take you directly to the Rand Health Survey Site)

Russell Smoking Motivations Questionnaire (RSMQ)

Russell MAH, Peto J, Patel V (1974).  The classification of smoking by factorial structure of motives.  J Royal Statistics Society; 37:313-346.

Wisconsin Inventory of Smoking Dependence Motives (WISDM)


This link will take you directly to the Psychological Assessment Resources site