Version 10.0 (October 2020)
DESCRIPTIVE INFORMATION BY DIAGNOSTIC MODEL
MODEL 1: DSM-IV or DSM-IIIR Nicotine Dependence or FTND>=4 or study-defined case (see notes for definition)
MODEL 2: Model 1 or DSM-IV or DSM-IIIR Alcohol Dependence
MODEL 3: Model 2 or DSM-IV or DSM-IIIR Illicit drug dependence (cocaine, opioid, cannabis, sedative, stimulant, other)
| Description | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| PEDIGREES WITH AN AFFECTED SIB-PAIR WITH DNA AVAILABLE | |||
| # sibships, 2 affected sibs with DNA available | 663 | 673 | 674 |
| # sibships, 3 affected sibs with DNA available | 200 | 218 | 221 |
| # sibships, 4 affected sibs with DNA available | 29 | 29 | 31 |
| # sibships, 5 or more affected sibs with DNA available | 22 | 27 | 27 |
| Total # pedigrees,at least 1 affected sib-pair with DNA available | 907 | 940 | 946 |
| # affected sib-pairs with DNA available (n-1) | 1247 | 1317 | 1330 |
| Maximum # affected sib-pairs with DNA available [n*(n-1)/2] | 1706 | 1842 | 1864 |
| # affected sibs with DNA available | 2161 | 2264 | 2283 |
| # other affected relatives with DNA available | 141 | 147 | 147 |
| Total # affecteds with DNA available | 2302 | 2411 | 2430 |
| # unaffected sibs with DNA available | 378 | 351 | 344 |
| # other unaffected relatives with DNA available | 518 | 541 | 546 |
| Total # subjects with DNA available | 3198 | 3303 | 3320 |
| # sibships, no parent with DNA available | 427 | 442 | 445 |
| # sibships, 1 parent with DNA available | 359 | 372 | 373 |
| # sibships, both parents with DNA available | 174 | 188 | 190 |
| # afffecteds with DNA available, by sex | |||
| Female | 1347 | 1391 | 1401 |
| Male | 955 | 1020 | 1029 |
| PEDIGREES WITHOUT AN AFFECTED SIB-PAIR WITH DNA AVAILABLE | |||
| # pedigrees, one affected with DNA available | 5153 | 5247 | 5296 |
| # pedigrees, 2 affecteds with DNA available | 256 | 262 | 263 |
| # pedigrees, 3 affecteds with DNA available | 80 | 84 | 87 |
| # pedigrees, 4 affecteds with DNA available | 0 | 0 | 0 |
| # sibships, 5 or more affecteds with DNA available | 0 | 0 | 0 |
| Total # pedigrees, at least 1 affected with DNA available | 5489 | 5593 | 5646 |
| Total # affecteds with DNA available | 5905 | 6023 | 6083 |
| Total # subjects with DNA available | 9162 | 9057 | 9040 |
| TRIOS FOR ASSOCIATION ANALYSIS | |||
| (AN AFFECTED INDIVIDUAL + 2 PARENTS WITH DNA AVAILABLE) | |||
| # pedigrees containing at least 1 trio | 546 | 563 | 570 |
| INDEPENDENT CASES AND CONTROLS | |||
| # independent cases | 6396 | 6533 | 6592 |
| # independent controls in distribution file | 0 | 0 | 0 |